Due to a recent medical experiment, scientists develop new exercise-mimicking drug to treat obesity and type 2 diabetes. The experiment was conducted on lab mice and it proved that the exercise-mimicking molecule called Compound 14 inhibits production of the ATIC enzyme which has been many times related to increased body fat.
The research was conducted by scientists at the University of Southampton in Britain and was supervised by professors Ali Tavassoli and Felino Cagampang. The leaders of the study claim the research they have carried out has enabled them to identify a molecule that tricks the body into thinking that it is making physical exercises and it, therefore, requires more energy.
The diligent molecule is called Compound 14 and it is responsible for the inhibition of the ATIC enzyme. The latter enzyme is the only one that determines the levels of insulin in the body, based on which the ZMP regulator is produced.
According to scientists’ description, the ZMP molecule works as a regulator of the metabolism programming the brain to consume more energy. When combined with Compound 14, ZMP sends low-energy signals to the brain, which in turn, increases glucose levels in the metabolism.
These changes are specific for physical exercises, which explains why the lab mice that have been used for this current tests lost weight during the experiment. Although many other tests should be conducted to verify the effectiveness of Compound 14 on humans, scientists take great confidence in this new finding.
They believe Compound 14 could be used in the development of future pills for the treatment of type 2 diabetes and obesity. The exercise-mimicking molecule may be used under any form; it may be administered as a pill and help people lose weight without going through the efforts of physical exercises.
The experiment implied the administration of Compound 14 to two groups of mice. The mice in the first category were on a normal diet, whereas the mice in the second category followed a high-fat diet which made them obese and diabetic, as a result of their uneven levels of glucose.
At the end of the experiment, scientists have noticed that the normal-diet mice maintained their body weight and glucose levels, whereas the ones with a highly caloric regime lost approximately 5 percent of their body weight. These results were obtained after one week during which mice were administered a single dose of Compound 14.
Scientists have concluded that the best benefit of Compound 14 is the fact that it helps reduce body mass and regulates glucose levels only in obese mice. The next step they plan on achieving is to study the long term effects of the compound on patients with weight problems.
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